Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation
Inconsistent expression and regulation of drug-metabolizing enzymes (DMEs) are common causes of adverse drug effects in some drugs with a narrow therapeutic index (TI). An important cytochrome, cytochrome P450 3A4 (CYP3A4), is predominantly regulated by a nuclear receptor, pregnane X receptor (PXR)....
Main Authors: | Yun-Ping Lim, Chia-Yun Ma, Cheng-Ling Liu, Yu-Hsien Lin, Miao-Lin Hu, Jih-Jung Chen, Dong-Zong Hung, Wen-Tsong Hsieh, Jin-Ding Huang |
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Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2012-01-01
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Series: | Evidence-Based Complementary and Alternative Medicine |
Online Access: | http://dx.doi.org/10.1155/2012/242810 |
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