Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors

Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors

Abstract Background The expression of a specific combination of transcription factors (TFs) in the multipotent progenitor cells (MPCs) is critical for determining pancreatic cell fate. NKX6.1 expression in PDX1+ MPCs is required for functional β cell generation. We have recently demonstrated the gen...

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Bibliographic Details
Main Authors: Idil I. Aigha, Bushra Memon, Ahmed K. Elsayed, Essam M. Abdelalim
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Stem Cell Research & Therapy
Subjects:
hESCs
hiPSCs
Pancreatic development
Transcription factors
Pancreatic progenitors
β cells
Online Access:http://link.springer.com/article/10.1186/s13287-018-0834-0

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http://link.springer.com/article/10.1186/s13287-018-0834-0

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