Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors
Abstract Background The expression of a specific combination of transcription factors (TFs) in the multipotent progenitor cells (MPCs) is critical for determining pancreatic cell fate. NKX6.1 expression in PDX1+ MPCs is required for functional β cell generation. We have recently demonstrated the gen...
Main Authors: | Idil I. Aigha, Bushra Memon, Ahmed K. Elsayed, Essam M. Abdelalim |
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Format: | Article |
Language: | English |
Published: |
BMC
2018-04-01
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Series: | Stem Cell Research & Therapy |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13287-018-0834-0 |
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