Selonsertib Alleviates the Progression of Rat Osteoarthritis: An in vitro and in vivo Study

Selonsertib Alleviates the Progression of Rat Osteoarthritis: An in vitro and in vivo Study

Osteoarthritis (OA) is a prevalent degenerative joint disease. Its development is highly associated with inflammatory response and apoptosis in chondrocytes. Selonsertib (Ser), the inhibitor of Apoptosis Signal-regulated kinase-1 (ASK1), has exhibited multiple therapeutic effects in several diseases...

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Bibliographic Details
Main Authors: Jiyuan Yan, Yingchi Zhang, Gaohong Sheng, Bowei Ni, Yifan Xiao, Shanxi Wang, Tianqi Wang, Yongzhuang Ma, Huaixi Wang, Hua Wu, Chang Tu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
selonsertib
osteoarthritis
apotosis
ASK1
p38
JNK
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.687033/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.687033/full

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