Renal vein thrombosis, light-chain deposition disease and cast nephropathy in a multiple myeloma patient
A 56-year-old woman presented with thoracic pain and dyspnea for 3 days. She had been under treatment for systemic arterial hypertension for 16 years. Laboratory investigation showed acute renal failure with indication for hemodialysis. After dialysis, despite improvements in clinical and laboratory...
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University of São Paulo
2011-06-01
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doaj-deb3f2769976467e8b7e18b2e8807a2b2020-11-24T21:13:40ZengUniversity of São PauloAutopsy and Case Reports2236-19602011-06-011210.4322/acr.2016.00636326Renal vein thrombosis, light-chain deposition disease and cast nephropathy in a multiple myeloma patientVilma TakayasuSilvana Maria LovisoloLeonardo de Abreu TestagrossaAloísio Felipe-SilvaA 56-year-old woman presented with thoracic pain and dyspnea for 3 days. She had been under treatment for systemic arterial hypertension for 16 years. Laboratory investigation showed acute renal failure with indication for hemodialysis. After dialysis, despite improvements in clinical and laboratory parameters, she had an episode of ventricular fibrillation and cardiac arrest which was promptly reverted. She was still oliguric but without neurological deficits. A laboratory work up for multiple myeloma was started. Serum protein electrophoresis showed hypogammaglobulinemia without a monoclonal peak. While on laboratory work up, the patient had another episode of ventricular fibrillation and died. The autopsy showed left renal vein thrombosis, bone marrow involvement by a plasmacytic myeloma, light-chain deposition disease with diffuse glomerular and tubular involvement and also myeloma cast nephropathy. This case illustrates a rarely documented association between myeloma cast nephropathy, renal light-chain deposition disease and renal vein thrombosis in a multiple myeloma patient with acute renal failure.http://www.revistas.usp.br/autopsy/article/view/36418Multiple myelomaAutopsyThrombosisAcute kidney injuryMyeloma proteins. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vilma Takayasu Silvana Maria Lovisolo Leonardo de Abreu Testagrossa Aloísio Felipe-Silva |
spellingShingle |
Vilma Takayasu Silvana Maria Lovisolo Leonardo de Abreu Testagrossa Aloísio Felipe-Silva Renal vein thrombosis, light-chain deposition disease and cast nephropathy in a multiple myeloma patient Autopsy and Case Reports Multiple myeloma Autopsy Thrombosis Acute kidney injury Myeloma proteins. |
author_facet |
Vilma Takayasu Silvana Maria Lovisolo Leonardo de Abreu Testagrossa Aloísio Felipe-Silva |
author_sort |
Vilma Takayasu |
title |
Renal vein thrombosis, light-chain deposition disease and cast nephropathy in a multiple myeloma patient |
title_short |
Renal vein thrombosis, light-chain deposition disease and cast nephropathy in a multiple myeloma patient |
title_full |
Renal vein thrombosis, light-chain deposition disease and cast nephropathy in a multiple myeloma patient |
title_fullStr |
Renal vein thrombosis, light-chain deposition disease and cast nephropathy in a multiple myeloma patient |
title_full_unstemmed |
Renal vein thrombosis, light-chain deposition disease and cast nephropathy in a multiple myeloma patient |
title_sort |
renal vein thrombosis, light-chain deposition disease and cast nephropathy in a multiple myeloma patient |
publisher |
University of São Paulo |
series |
Autopsy and Case Reports |
issn |
2236-1960 |
publishDate |
2011-06-01 |
description |
A 56-year-old woman presented with thoracic pain and dyspnea for 3 days. She had been under treatment for systemic arterial hypertension for 16 years. Laboratory investigation showed acute renal failure with indication for hemodialysis. After dialysis, despite improvements in clinical and laboratory parameters, she had an episode of ventricular fibrillation
and cardiac arrest which was promptly reverted. She was still oliguric but without neurological deficits. A laboratory work up for multiple myeloma was started. Serum protein electrophoresis showed hypogammaglobulinemia without a monoclonal peak. While on laboratory work up, the patient had another episode of ventricular fibrillation and died. The
autopsy showed left renal vein thrombosis, bone marrow involvement by a plasmacytic myeloma, light-chain deposition disease with diffuse glomerular and tubular involvement
and also myeloma cast nephropathy. This case illustrates a rarely documented association between myeloma cast nephropathy, renal light-chain deposition disease and renal
vein thrombosis in a multiple myeloma patient with acute renal failure. |
topic |
Multiple myeloma Autopsy Thrombosis Acute kidney injury Myeloma proteins. |
url |
http://www.revistas.usp.br/autopsy/article/view/36418 |
work_keys_str_mv |
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