Sleeve Gastrectomy and Roux-En-Y Gastric Bypass. Two Sculptors of the Pancreatic Islet

Several surgical procedures are performed for the treatment of obesity. A main outcome of these procedures is the improvement of type 2 diabetes mellitus. Trying to explain this, gastrointestinal hormone levels and their effect on organs involved in carbohydrate metabolism, such as liver, gut, muscl...

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Main Authors: Gonzalo-Martín Pérez-Arana, José Fernández-Vivero, Alonso Camacho-Ramírez, Alfredo Díaz Gómez, José Bancalero de los Reyes, Antonio Ribelles-García, David Almorza-Gomar, Carmen Carrasco-Molinillo, José-Arturo Prada-Oliveira
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Journal of Clinical Medicine
Subjects:
Online Access:https://www.mdpi.com/2077-0383/10/18/4217
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spelling doaj-df6ef85baa9240458a2081265b938b502021-09-26T00:28:39ZengMDPI AGJournal of Clinical Medicine2077-03832021-09-01104217421710.3390/jcm10184217Sleeve Gastrectomy and Roux-En-Y Gastric Bypass. Two Sculptors of the Pancreatic IsletGonzalo-Martín Pérez-Arana0José Fernández-Vivero1Alonso Camacho-Ramírez2Alfredo Díaz Gómez3José Bancalero de los Reyes4Antonio Ribelles-García5David Almorza-Gomar6Carmen Carrasco-Molinillo7José-Arturo Prada-Oliveira8Department of Human Anatomy and Embryology, Faculty of Medicine, University of Cadiz, 11003 Cadiz, SpainDepartment of Human Anatomy and Embryology, Faculty of Medicine, University of Cadiz, 11003 Cadiz, SpainDepartment of Human Anatomy and Embryology, Faculty of Medicine, University of Cadiz, 11003 Cadiz, SpainSan Carlos Hospital, Andalusian Health System, 28040 Madrid, SpainBadajoz Hospital, Extremadura Health System, 06001 Badajoz, SpainDepartment of Human Anatomy and Embryology, Faculty of Medicine, University of Cadiz, 11003 Cadiz, SpainInstitute for Biomedical Science Research and Innovation (INIBICA), University of Cadiz, 11003 Cadiz, SpainDepartment of Human Anatomy and Embryology, Faculty of Medicine, University of Cadiz, 11003 Cadiz, SpainDepartment of Human Anatomy and Embryology, Faculty of Medicine, University of Cadiz, 11003 Cadiz, SpainSeveral surgical procedures are performed for the treatment of obesity. A main outcome of these procedures is the improvement of type 2 diabetes mellitus. Trying to explain this, gastrointestinal hormone levels and their effect on organs involved in carbohydrate metabolism, such as liver, gut, muscle or fat, have been studied intensively after bariatric surgery. These effects on endocrine-cell populations in the pancreas have been less well studied. We gathered the existing data on these pancreatic-cell populations after the two most common types of bariatric surgery, the sleeve gastrectomy (SG) and the roux-en-Y gastric bypass (RYGB), with the aim to explain the pathophysiological mechanisms underlying these surgeries and to improve their outcome.https://www.mdpi.com/2077-0383/10/18/4217sleeve gastrectomyroux-en-Y gastric bypassbeta-cellalpha-cellepsilon-cellislet
collection DOAJ
language English
format Article
sources DOAJ
author Gonzalo-Martín Pérez-Arana
José Fernández-Vivero
Alonso Camacho-Ramírez
Alfredo Díaz Gómez
José Bancalero de los Reyes
Antonio Ribelles-García
David Almorza-Gomar
Carmen Carrasco-Molinillo
José-Arturo Prada-Oliveira
spellingShingle Gonzalo-Martín Pérez-Arana
José Fernández-Vivero
Alonso Camacho-Ramírez
Alfredo Díaz Gómez
José Bancalero de los Reyes
Antonio Ribelles-García
David Almorza-Gomar
Carmen Carrasco-Molinillo
José-Arturo Prada-Oliveira
Sleeve Gastrectomy and Roux-En-Y Gastric Bypass. Two Sculptors of the Pancreatic Islet
Journal of Clinical Medicine
sleeve gastrectomy
roux-en-Y gastric bypass
beta-cell
alpha-cell
epsilon-cell
islet
author_facet Gonzalo-Martín Pérez-Arana
José Fernández-Vivero
Alonso Camacho-Ramírez
Alfredo Díaz Gómez
José Bancalero de los Reyes
Antonio Ribelles-García
David Almorza-Gomar
Carmen Carrasco-Molinillo
José-Arturo Prada-Oliveira
author_sort Gonzalo-Martín Pérez-Arana
title Sleeve Gastrectomy and Roux-En-Y Gastric Bypass. Two Sculptors of the Pancreatic Islet
title_short Sleeve Gastrectomy and Roux-En-Y Gastric Bypass. Two Sculptors of the Pancreatic Islet
title_full Sleeve Gastrectomy and Roux-En-Y Gastric Bypass. Two Sculptors of the Pancreatic Islet
title_fullStr Sleeve Gastrectomy and Roux-En-Y Gastric Bypass. Two Sculptors of the Pancreatic Islet
title_full_unstemmed Sleeve Gastrectomy and Roux-En-Y Gastric Bypass. Two Sculptors of the Pancreatic Islet
title_sort sleeve gastrectomy and roux-en-y gastric bypass. two sculptors of the pancreatic islet
publisher MDPI AG
series Journal of Clinical Medicine
issn 2077-0383
publishDate 2021-09-01
description Several surgical procedures are performed for the treatment of obesity. A main outcome of these procedures is the improvement of type 2 diabetes mellitus. Trying to explain this, gastrointestinal hormone levels and their effect on organs involved in carbohydrate metabolism, such as liver, gut, muscle or fat, have been studied intensively after bariatric surgery. These effects on endocrine-cell populations in the pancreas have been less well studied. We gathered the existing data on these pancreatic-cell populations after the two most common types of bariatric surgery, the sleeve gastrectomy (SG) and the roux-en-Y gastric bypass (RYGB), with the aim to explain the pathophysiological mechanisms underlying these surgeries and to improve their outcome.
topic sleeve gastrectomy
roux-en-Y gastric bypass
beta-cell
alpha-cell
epsilon-cell
islet
url https://www.mdpi.com/2077-0383/10/18/4217
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