A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases

A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseases

Abstract Background Genomic medicine has paved the way for identifying biomarkers and therapeutically actionable targets for complex diseases, but is complicated by the involvement of thousands of variably expressed genes across multiple cell types. Single-cell RNA-sequencing study (scRNA-seq) allow...

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Bibliographic Details
Main Authors: Danuta R. Gawel, Jordi Serra-Musach, Sandra Lilja, Jesper Aagesen, Alex Arenas, Bengt Asking, Malin Bengnér, Janne Björkander, Sophie Biggs, Jan Ernerudh, Henrik Hjortswang, Jan-Erik Karlsson, Mattias Köpsen, Eun Jung Lee, Antonio Lentini, Xinxiu Li, Mattias Magnusson, David Martínez-Enguita, Andreas Matussek, Colm E. Nestor, Samuel Schäfer, Oliver Seifert, Ceylan Sonmez, Henrik Stjernman, Andreas Tjärnberg, Simon Wu, Karin Åkesson, Alex K. Shalek, Margaretha Stenmarker, Huan Zhang, Mika Gustafsson, Mikael Benson
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Genome Medicine
Subjects:
Network tools
scRNA-seq
Biomarker and drug discovery
Online Access:http://link.springer.com/article/10.1186/s13073-019-0657-3

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http://link.springer.com/article/10.1186/s13073-019-0657-3

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