Depletion of Cholesterol Reduces ENaC Activity by Decreasing Phosphatidylinositol-4,5-Bisphosphate in Microvilli

Depletion of Cholesterol Reduces ENaC Activity by Decreasing Phosphatidylinositol-4,5-Bisphosphate in Microvilli

Background/Aims: The epithelial sodium channel (ENaC) in cortical collecting duct (CCD) principal cells plays a critical role in regulating systemic blood pressure. We have previously shown that cholesterol (Cho) in the apical cell membrane regulates ENaC; however, the underlying mechanism remains u...

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Bibliographic Details
Main Authors: Yu-Jia Zhai, Bing-Chen Liu, Shi-Peng Wei, Chu-Fang Chou, Ming-Ming Wu, Bin-Lin Song, Valerie A. Linck, Li Zou, Shuai Zhang, Xue-Qi Li, Zhi-Ren Zhang, He-Ping Ma
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
ENaC
PIP2
Methyl-β-cyclodextrin
Lovastatin
Patch-clamp technique
Confocal microscopy
Online Access:https://www.karger.com/Article/FullText/490170

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https://www.karger.com/Article/FullText/490170

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