NLRP3 Inflammasome Mediates Dormant Neutrophil Recruitment following Sterile Lung Injury and Protects against Subsequent Bacterial Pneumonia in Mice

NLRP3 Inflammasome Mediates Dormant Neutrophil Recruitment following Sterile Lung Injury and Protects against Subsequent Bacterial Pneumonia in Mice

Sterile lung injury is an important clinical problem that complicates the course of severely ill patients. Interruption of blood flow, namely ischemia–reperfusion (IR), initiates a sterile inflammatory response in the lung that is believed to be maladaptive. The rationale for this study was to eluci...

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Bibliographic Details
Main Authors: Xiaoli Tian, He Sun, Amy-Jo Casbon, Edward Lim, Kevin P. Francis, Judith Hellman, Arun Prakash
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
lung injury
inflammasome
NOD-
LRR-
and pyrin domain-containing 3
interleukin-1β
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01337/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01337/full

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