Right‐ventricular dysfunction in HFpEF is linked to altered cardiomyocyte Ca2+ homeostasis and myofilament sensitivity

Right‐ventricular dysfunction in HFpEF is linked to altered cardiomyocyte Ca2+ homeostasis and myofilament sensitivity

Abstract Aims Heart failure with preserved ejection fraction (HFpEF) is frequently (30%) associated with right ventricular (RV) dysfunction, which increases morbidity and mortality in these patients. Yet cellular mechanisms of RV remodelling and RV dysfunction in HFpEF are not well understood. Here,...

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Bibliographic Details
Main Authors: Niklas Hegemann, Uwe Primessnig, David Bode, Paulina Wakula, Nicola Beindorff, Robert Klopfleisch, Laura Michalick, Jana Grune, Felix Hohendanner, Daniel Messroghli, Burkert Pieske, Wolfgang M. Kuebler, Frank R. Heinzel
Format: Article
Language:English
Published: Wiley 2021-08-01
Series:ESC Heart Failure
Subjects:
Right ventricular dysfunction
Heart failure with preserved ejection fraction
Myofilament sensitivity
Calcium
ZSF‐1 obese rats
Online Access:https://doi.org/10.1002/ehf2.13419

Internet

https://doi.org/10.1002/ehf2.13419

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