Bardet–Biedl syndrome 3 protein promotes ciliary exit of the signaling protein phospholipase D via the BBSome

Bardet–Biedl syndrome 3 protein promotes ciliary exit of the signaling protein phospholipase D via the BBSome

Certain ciliary signaling proteins couple with the BBSome, a conserved complex of Bardet–Biedl syndrome (BBS) proteins, to load onto retrograde intraflagellar transport (IFT) trains for their removal out of cilia in Chlamydomonas reinhardtii. Here, we show that loss of the Arf-like 6 (ARL6) GTPase B...

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Bibliographic Details
Main Authors: Yan-Xia Liu, Bin Xue, Wei-Yue Sun, Jenna L Wingfield, Jun Sun, Mingfu Wu, Karl F Lechtreck, Zhenlong Wu, Zhen-Chuan Fan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
cilia
BBS3
BBSome
intraflagellar transport
phospholipase D
Online Access:https://elifesciences.org/articles/59119

Internet

https://elifesciences.org/articles/59119

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