The impact of fluid status and decremental PEEP strategy on cardiac function and lung and kidney damage in mild-moderate experimental acute respiratory distress syndrome

Abstract Background We evaluated the effects of abrupt versus gradual PEEP decrease, combined with standard versus high-volume fluid administration, on cardiac function, as well as lung and kidney damage in an established model of mild-moderate acute respiratory distress syndrome (ARDS). Methods Wis...

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Bibliographic Details
Main Authors: Nazareth N. Rocha, Cynthia S. Samary, Mariana A. Antunes, Milena V. Oliveira, Matheus R. Hemerly, Patrine S. Santos, Vera L. Capelozzi, Fernanda F. Cruz, John J. Marini, Pedro L. Silva, Paolo Pelosi, Patricia R. M. Rocco
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Respiratory Research
Subjects:
Online Access:https://doi.org/10.1186/s12931-021-01811-y