Mevalonate Pathway Blockade, Mitochondrial Dysfunction and Autophagy: A Possible Link

Mevalonate Pathway Blockade, Mitochondrial Dysfunction and Autophagy: A Possible Link

The mevalonate pathway, crucial for cholesterol synthesis, plays a key role in multiple cellular processes. Deregulation of this pathway is also correlated with diminished protein prenylation, an important post-translational modification necessary to localize certain proteins, such as small GTPases,...

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Bibliographic Details
Main Authors: Paola Maura Tricarico, Sergio Crovella, Fulvio Celsi
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:International Journal of Molecular Sciences
Subjects:
autophagy
mevalonate pathway
mitochondrial dysfunction
inflammation
Mevalonate Kinase Deficiency
statins
Online Access:http://www.mdpi.com/1422-0067/16/7/16067

Internet

http://www.mdpi.com/1422-0067/16/7/16067

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