Natural Course of Clinically Isolated Syndrome: A Longitudinal Analysis Using a Markov Model

Abstract Clinically isolated syndrome (CIS) refers to the initial clinical episode with symptoms suggestive of multiple sclerosis (MS). Due to limited number of long-term follow-up studies, progression pattern from CIS to more advanced stages remains unclear. In the current study, we constructed a M...

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Bibliographic Details
Main Authors: Yuli Hou, Yujuan Jia, Jingtian Hou
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-29206-y