Activation of the Nlrp3 Inflammasome Contributes to Shiga Toxin-Induced Hemolytic Uremic Syndrome in a Mouse Model

Activation of the Nlrp3 Inflammasome Contributes to Shiga Toxin-Induced Hemolytic Uremic Syndrome in a Mouse Model

ObjectiveTo explore the role of the Nlrp3 inflammasome activation in the development of hemolytic uremic syndrome (HUS) induced by Stx2 and evaluate the efficacy of small molecule Nlrp3 inhibitors in preventing the HUS.MethodsPeritoneal macrophages (PMs) isolated from wild-type (WT) C57BL/6J mice an...

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Bibliographic Details
Main Authors: Liqiong Song, Yuchun Xiao, Xianping Li, Yuanming Huang, Guangxun Meng, Zhihong Ren
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
Stx2
hemolytic uremic syndrome
IL-1β
Nlrp3
Nlrp3 inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.619096/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.619096/full

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