Oncogenic B-Myb Is Associated With Deregulation of the DREAM-Mediated Cell Cycle Gene Expression Program in High Grade Serous Ovarian Carcinoma Clinical Tumor Samples

Oncogenic B-Myb Is Associated With Deregulation of the DREAM-Mediated Cell Cycle Gene Expression Program in High Grade Serous Ovarian Carcinoma Clinical Tumor Samples

Cell cycle control drives cancer progression and treatment response in high grade serous ovarian carcinoma (HGSOC). MYBL2 (encoding B-Myb), an oncogene with prognostic significance in several cancers, is highly expressed in most HGSOC cases; however, the clinical significance of B-Myb in this diseas...

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Bibliographic Details
Main Authors: Audra N. Iness, Lisa Rubinsak, Steven J. Meas, Jessica Chaoul, Sadia Sayeed, Raghavendra Pillappa, Sarah M. Temkin, Mikhail G. Dozmorov, Larisa Litovchick
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
MYBL2
DYRK1A
cancer genome atlas
protein complex
transcription
FoxM1
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.637193/full

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