Infectious Causes of Cholesteatoma and Treatment of Infected Ossicles prior to Reimplantation by Hydrostatic High-Pressure Inactivation
Chronic inflammation, which is caused by recurrent infections, is one of the factors contributing to the pathogenesis of cholesteatoma. If reimplantation of autologous ossicles after a surgical intervention is intended, inactivation of planktonic bacteria and biofilms is desirable. High hydrostatic...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2015-01-01
|
Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2015/761259 |
id |
doaj-e1f34fd586d643d6968165bf271a1298 |
---|---|
record_format |
Article |
spelling |
doaj-e1f34fd586d643d6968165bf271a12982020-11-24T22:28:07ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/761259761259Infectious Causes of Cholesteatoma and Treatment of Infected Ossicles prior to Reimplantation by Hydrostatic High-Pressure InactivationWycliffe Omurwa Masanta0Rebecca Hinz1Andreas Erich Zautner2Institut für Medizinische Mikrobiologie, Universitätsmedizin Göttingen, 37075 Göttingen, GermanyFachbereich Tropenmedizin am Bernhard-Nocht-Institut, Bundeswehrkrankenhaus Hamburg, 20359 Hamburg, GermanyInstitut für Medizinische Mikrobiologie, Universitätsmedizin Göttingen, 37075 Göttingen, GermanyChronic inflammation, which is caused by recurrent infections, is one of the factors contributing to the pathogenesis of cholesteatoma. If reimplantation of autologous ossicles after a surgical intervention is intended, inactivation of planktonic bacteria and biofilms is desirable. High hydrostatic pressure treatment is a procedure, which has been used to inactivate cholesteatoma cells on ossicles. Here we discuss the potential inactivating effect of high hydrostatic pressure on microbial pathogens including biofilms. Recent experimental data suggest an incomplete inactivation at a pressure level, which is tolerable for the bone substance of ossicles and results at least in a considerable reduction of pathogen load. Further studies are necessary to access how far this quantitative reduction of pathogens is sufficient to prevent ongoing chronic infections, for example, due to forming of biofilms.http://dx.doi.org/10.1155/2015/761259 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wycliffe Omurwa Masanta Rebecca Hinz Andreas Erich Zautner |
spellingShingle |
Wycliffe Omurwa Masanta Rebecca Hinz Andreas Erich Zautner Infectious Causes of Cholesteatoma and Treatment of Infected Ossicles prior to Reimplantation by Hydrostatic High-Pressure Inactivation BioMed Research International |
author_facet |
Wycliffe Omurwa Masanta Rebecca Hinz Andreas Erich Zautner |
author_sort |
Wycliffe Omurwa Masanta |
title |
Infectious Causes of Cholesteatoma and Treatment of Infected Ossicles prior to Reimplantation by Hydrostatic High-Pressure Inactivation |
title_short |
Infectious Causes of Cholesteatoma and Treatment of Infected Ossicles prior to Reimplantation by Hydrostatic High-Pressure Inactivation |
title_full |
Infectious Causes of Cholesteatoma and Treatment of Infected Ossicles prior to Reimplantation by Hydrostatic High-Pressure Inactivation |
title_fullStr |
Infectious Causes of Cholesteatoma and Treatment of Infected Ossicles prior to Reimplantation by Hydrostatic High-Pressure Inactivation |
title_full_unstemmed |
Infectious Causes of Cholesteatoma and Treatment of Infected Ossicles prior to Reimplantation by Hydrostatic High-Pressure Inactivation |
title_sort |
infectious causes of cholesteatoma and treatment of infected ossicles prior to reimplantation by hydrostatic high-pressure inactivation |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2015-01-01 |
description |
Chronic inflammation, which is caused by recurrent infections, is one of the factors contributing to the pathogenesis of cholesteatoma. If reimplantation of autologous ossicles after a surgical intervention is intended, inactivation of planktonic bacteria and biofilms is desirable. High hydrostatic pressure treatment is a procedure, which has been used to inactivate cholesteatoma cells on ossicles. Here we discuss the potential inactivating effect of high hydrostatic pressure on microbial pathogens including biofilms. Recent experimental data suggest an incomplete inactivation at a pressure level, which is tolerable for the bone substance of ossicles and results at least in a considerable reduction of pathogen load. Further studies are necessary to access how far this quantitative reduction of pathogens is sufficient to prevent ongoing chronic infections, for example, due to forming of biofilms. |
url |
http://dx.doi.org/10.1155/2015/761259 |
work_keys_str_mv |
AT wycliffeomurwamasanta infectiouscausesofcholesteatomaandtreatmentofinfectedossiclespriortoreimplantationbyhydrostatichighpressureinactivation AT rebeccahinz infectiouscausesofcholesteatomaandtreatmentofinfectedossiclespriortoreimplantationbyhydrostatichighpressureinactivation AT andreaserichzautner infectiouscausesofcholesteatomaandtreatmentofinfectedossiclespriortoreimplantationbyhydrostatichighpressureinactivation |
_version_ |
1725747785056124928 |