Cloning, expression and identification of KTX-Sp4, a selective Kv1.3 peptidic blocker from Scorpiops pococki

Cloning, expression and identification of KTX-Sp4, a selective Kv1.3 peptidic blocker from Scorpiops pococki

Abstract Background Specific and selective peptidic blockers of Kv1.3 channels can serve as a valuable drug lead for treating T cell-mediated autoimmune diseases, and scorpion venom is an important source of kv1.3 channel inhibitors. Through conducting transcriptomic sequencing for the venom gland o...

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Bibliographic Details
Main Authors: Yan Zou, Feng Zhang, Yaxian Li, Yuanfang Wang, Yi Li, Zhengtao Long, Shujuan Shi, Li Shuai, Jiukai Liu, Zhiyong Di, Shijin Yin
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Cell & Bioscience
Subjects:
Peptide KTX-Sp4
Scorpiops pococki
Kv1.3
Channel turret
Selectivity
Online Access:http://link.springer.com/article/10.1186/s13578-017-0187-x

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http://link.springer.com/article/10.1186/s13578-017-0187-x

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