Allergen-specific IgE and IgG4 patterns among patients with different allergic diseases
Abstract Background In addition to allergen-specific IgE (sIgE), allergen-specific IgG4 (sIgG4) antibodies are also involved in the immune response resulting from an allergen exposure. The aim of our study was to analyze sIgE and sIgG4 patterns in the most common allergic disorders: bronchial asthma...
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doaj-e2e6d66df5464259a89b1c27bdc7f2942020-11-25T01:00:24ZengElsevierWorld Allergy Organization Journal1939-45512018-12-0111111010.1186/s40413-018-0220-5Allergen-specific IgE and IgG4 patterns among patients with different allergic diseasesOlga Smoldovskaya0Guzel Feyzkhanova1Sergei Voloshin2Alla Arefieva3Antonina Chubarova4Ludmila Pavlushkina5Tatiana Filatova6Eugenia Antonova7Elena Timofeeva8Veronika Butvilovskaya9Yuri Lysov10Alexander Zasedatelev11Alla Rubina12Engelhardt Institute of Molecular Biology, Russian Academy of SciencesEngelhardt Institute of Molecular Biology, Russian Academy of SciencesEngelhardt Institute of Molecular Biology, Russian Academy of SciencesEngelhardt Institute of Molecular Biology, Russian Academy of SciencesFilatov Moscow City Pediatric Clinic No. 13Filatov Moscow City Pediatric Clinic No. 13Filatov Moscow City Pediatric Clinic No. 13Filatov Moscow City Pediatric Clinic No. 13Filatov Moscow City Pediatric Clinic No. 13Engelhardt Institute of Molecular Biology, Russian Academy of SciencesEngelhardt Institute of Molecular Biology, Russian Academy of SciencesEngelhardt Institute of Molecular Biology, Russian Academy of SciencesEngelhardt Institute of Molecular Biology, Russian Academy of SciencesAbstract Background In addition to allergen-specific IgE (sIgE), allergen-specific IgG4 (sIgG4) antibodies are also involved in the immune response resulting from an allergen exposure. The aim of our study was to analyze sIgE and sIgG4 patterns in the most common allergic disorders: bronchial asthma, upper airway disorders and atopic dermatitis. Methods In this study a screening analysis of blood serum samples from 673 patients aged from 6 months to 17 years with different allergic entities was performed on microarrays. sIgE and sIgG4 levels to the most common allergens were estimated. Results sIgE response to most pollen allergens is more strongly associated with respiratory diseases than with atopic dermatitis, while sIgE responses to cat and dog dander are more strongly associated with bronchial asthma than with atopic dermatitis and upper airway disorders such as rhinosinusitis and allergic rhinitis. A lower prevalence of sIgG4 to pollen allergens in cases of atopic dermatitis is observed compared with that in cases of asthma and upper airway disorders. Analyzing all the allergic disorders, one can see that sIgG4 response to inhalant allergens is strongly associated with sensitization to the corresponding allergen. Conclusion Allergen-specific IgE and IgG4 patterns that are relevant to concrete allergic diseases differ by sIgE and sIgG4 prevalences to defined allergens.http://link.springer.com/article/10.1186/s40413-018-0220-5Allergy diagnosticsIgEIgG4MicroarraysSensitizationAsthma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Olga Smoldovskaya Guzel Feyzkhanova Sergei Voloshin Alla Arefieva Antonina Chubarova Ludmila Pavlushkina Tatiana Filatova Eugenia Antonova Elena Timofeeva Veronika Butvilovskaya Yuri Lysov Alexander Zasedatelev Alla Rubina |
spellingShingle |
Olga Smoldovskaya Guzel Feyzkhanova Sergei Voloshin Alla Arefieva Antonina Chubarova Ludmila Pavlushkina Tatiana Filatova Eugenia Antonova Elena Timofeeva Veronika Butvilovskaya Yuri Lysov Alexander Zasedatelev Alla Rubina Allergen-specific IgE and IgG4 patterns among patients with different allergic diseases World Allergy Organization Journal Allergy diagnostics IgE IgG4 Microarrays Sensitization Asthma |
author_facet |
Olga Smoldovskaya Guzel Feyzkhanova Sergei Voloshin Alla Arefieva Antonina Chubarova Ludmila Pavlushkina Tatiana Filatova Eugenia Antonova Elena Timofeeva Veronika Butvilovskaya Yuri Lysov Alexander Zasedatelev Alla Rubina |
author_sort |
Olga Smoldovskaya |
title |
Allergen-specific IgE and IgG4 patterns among patients with different allergic diseases |
title_short |
Allergen-specific IgE and IgG4 patterns among patients with different allergic diseases |
title_full |
Allergen-specific IgE and IgG4 patterns among patients with different allergic diseases |
title_fullStr |
Allergen-specific IgE and IgG4 patterns among patients with different allergic diseases |
title_full_unstemmed |
Allergen-specific IgE and IgG4 patterns among patients with different allergic diseases |
title_sort |
allergen-specific ige and igg4 patterns among patients with different allergic diseases |
publisher |
Elsevier |
series |
World Allergy Organization Journal |
issn |
1939-4551 |
publishDate |
2018-12-01 |
description |
Abstract Background In addition to allergen-specific IgE (sIgE), allergen-specific IgG4 (sIgG4) antibodies are also involved in the immune response resulting from an allergen exposure. The aim of our study was to analyze sIgE and sIgG4 patterns in the most common allergic disorders: bronchial asthma, upper airway disorders and atopic dermatitis. Methods In this study a screening analysis of blood serum samples from 673 patients aged from 6 months to 17 years with different allergic entities was performed on microarrays. sIgE and sIgG4 levels to the most common allergens were estimated. Results sIgE response to most pollen allergens is more strongly associated with respiratory diseases than with atopic dermatitis, while sIgE responses to cat and dog dander are more strongly associated with bronchial asthma than with atopic dermatitis and upper airway disorders such as rhinosinusitis and allergic rhinitis. A lower prevalence of sIgG4 to pollen allergens in cases of atopic dermatitis is observed compared with that in cases of asthma and upper airway disorders. Analyzing all the allergic disorders, one can see that sIgG4 response to inhalant allergens is strongly associated with sensitization to the corresponding allergen. Conclusion Allergen-specific IgE and IgG4 patterns that are relevant to concrete allergic diseases differ by sIgE and sIgG4 prevalences to defined allergens. |
topic |
Allergy diagnostics IgE IgG4 Microarrays Sensitization Asthma |
url |
http://link.springer.com/article/10.1186/s40413-018-0220-5 |
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