The Current and Future Treatment of Brain Metastases
Brain metastases are the most common intracranial malignancy, accounting for significant morbidity and mortality in oncology patients. The current treatment paradigm for brain metastasis depends on the patient’s overall health status, the primary tumor pathology, and the number and location of brain...
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doaj-e31d0123d99940a6afafe99ee8da555a2020-11-25T02:47:28ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2016-05-01310.3389/fsurg.2016.00030203085The Current and Future Treatment of Brain MetastasesDouglas A Hardesty0Peter eNakaji1Barrow Neurological InstituteBarrow Neurological InstituteBrain metastases are the most common intracranial malignancy, accounting for significant morbidity and mortality in oncology patients. The current treatment paradigm for brain metastasis depends on the patient’s overall health status, the primary tumor pathology, and the number and location of brain lesions. Herein, we review the modern management options for these tumors, including surgical resection, radiotherapy, and chemotherapy. Recent operative advances, such as fluorescence, confocal microscopy, and brachytherapy, are highlighted. With an increased understanding of the pathophysiology of brain metastasis come increased future therapeutic options. Therapy targeted to specific tumor molecular pathways, such as those involved in blood-brain barrier transgression, cell-cell adhesion, and angiogenesis, are also reviewed. A personalized plan for each patient, based on molecular characterizations of the tumor that are used to better target radiotherapy and chemotherapy, is undoubtedly the future of brain metastasis treatment.http://journal.frontiersin.org/Journal/10.3389/fsurg.2016.00030/fullRadiotherapychemotherapypersonalized medicineTreatmentbrain metastasis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Douglas A Hardesty Peter eNakaji |
spellingShingle |
Douglas A Hardesty Peter eNakaji The Current and Future Treatment of Brain Metastases Frontiers in Surgery Radiotherapy chemotherapy personalized medicine Treatment brain metastasis |
author_facet |
Douglas A Hardesty Peter eNakaji |
author_sort |
Douglas A Hardesty |
title |
The Current and Future Treatment of Brain Metastases |
title_short |
The Current and Future Treatment of Brain Metastases |
title_full |
The Current and Future Treatment of Brain Metastases |
title_fullStr |
The Current and Future Treatment of Brain Metastases |
title_full_unstemmed |
The Current and Future Treatment of Brain Metastases |
title_sort |
current and future treatment of brain metastases |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Surgery |
issn |
2296-875X |
publishDate |
2016-05-01 |
description |
Brain metastases are the most common intracranial malignancy, accounting for significant morbidity and mortality in oncology patients. The current treatment paradigm for brain metastasis depends on the patient’s overall health status, the primary tumor pathology, and the number and location of brain lesions. Herein, we review the modern management options for these tumors, including surgical resection, radiotherapy, and chemotherapy. Recent operative advances, such as fluorescence, confocal microscopy, and brachytherapy, are highlighted. With an increased understanding of the pathophysiology of brain metastasis come increased future therapeutic options. Therapy targeted to specific tumor molecular pathways, such as those involved in blood-brain barrier transgression, cell-cell adhesion, and angiogenesis, are also reviewed. A personalized plan for each patient, based on molecular characterizations of the tumor that are used to better target radiotherapy and chemotherapy, is undoubtedly the future of brain metastasis treatment. |
topic |
Radiotherapy chemotherapy personalized medicine Treatment brain metastasis |
url |
http://journal.frontiersin.org/Journal/10.3389/fsurg.2016.00030/full |
work_keys_str_mv |
AT douglasahardesty thecurrentandfuturetreatmentofbrainmetastases AT peterenakaji thecurrentandfuturetreatmentofbrainmetastases AT douglasahardesty currentandfuturetreatmentofbrainmetastases AT peterenakaji currentandfuturetreatmentofbrainmetastases |
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