The Current and Future Treatment of Brain Metastases

Brain metastases are the most common intracranial malignancy, accounting for significant morbidity and mortality in oncology patients. The current treatment paradigm for brain metastasis depends on the patient’s overall health status, the primary tumor pathology, and the number and location of brain...

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Main Authors: Douglas A Hardesty, Peter eNakaji
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Surgery
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fsurg.2016.00030/full
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spelling doaj-e31d0123d99940a6afafe99ee8da555a2020-11-25T02:47:28ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2016-05-01310.3389/fsurg.2016.00030203085The Current and Future Treatment of Brain MetastasesDouglas A Hardesty0Peter eNakaji1Barrow Neurological InstituteBarrow Neurological InstituteBrain metastases are the most common intracranial malignancy, accounting for significant morbidity and mortality in oncology patients. The current treatment paradigm for brain metastasis depends on the patient’s overall health status, the primary tumor pathology, and the number and location of brain lesions. Herein, we review the modern management options for these tumors, including surgical resection, radiotherapy, and chemotherapy. Recent operative advances, such as fluorescence, confocal microscopy, and brachytherapy, are highlighted. With an increased understanding of the pathophysiology of brain metastasis come increased future therapeutic options. Therapy targeted to specific tumor molecular pathways, such as those involved in blood-brain barrier transgression, cell-cell adhesion, and angiogenesis, are also reviewed. A personalized plan for each patient, based on molecular characterizations of the tumor that are used to better target radiotherapy and chemotherapy, is undoubtedly the future of brain metastasis treatment.http://journal.frontiersin.org/Journal/10.3389/fsurg.2016.00030/fullRadiotherapychemotherapypersonalized medicineTreatmentbrain metastasis
collection DOAJ
language English
format Article
sources DOAJ
author Douglas A Hardesty
Peter eNakaji
spellingShingle Douglas A Hardesty
Peter eNakaji
The Current and Future Treatment of Brain Metastases
Frontiers in Surgery
Radiotherapy
chemotherapy
personalized medicine
Treatment
brain metastasis
author_facet Douglas A Hardesty
Peter eNakaji
author_sort Douglas A Hardesty
title The Current and Future Treatment of Brain Metastases
title_short The Current and Future Treatment of Brain Metastases
title_full The Current and Future Treatment of Brain Metastases
title_fullStr The Current and Future Treatment of Brain Metastases
title_full_unstemmed The Current and Future Treatment of Brain Metastases
title_sort current and future treatment of brain metastases
publisher Frontiers Media S.A.
series Frontiers in Surgery
issn 2296-875X
publishDate 2016-05-01
description Brain metastases are the most common intracranial malignancy, accounting for significant morbidity and mortality in oncology patients. The current treatment paradigm for brain metastasis depends on the patient’s overall health status, the primary tumor pathology, and the number and location of brain lesions. Herein, we review the modern management options for these tumors, including surgical resection, radiotherapy, and chemotherapy. Recent operative advances, such as fluorescence, confocal microscopy, and brachytherapy, are highlighted. With an increased understanding of the pathophysiology of brain metastasis come increased future therapeutic options. Therapy targeted to specific tumor molecular pathways, such as those involved in blood-brain barrier transgression, cell-cell adhesion, and angiogenesis, are also reviewed. A personalized plan for each patient, based on molecular characterizations of the tumor that are used to better target radiotherapy and chemotherapy, is undoubtedly the future of brain metastasis treatment.
topic Radiotherapy
chemotherapy
personalized medicine
Treatment
brain metastasis
url http://journal.frontiersin.org/Journal/10.3389/fsurg.2016.00030/full
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