The role of BRAF V600 mutation in melanoma

The role of BRAF V600 mutation in melanoma

<p>Abstract</p> <p>BRAF is a serine/threonine protein kinase activating the MAP kinase/ERK-signaling pathway. About 50 % of melanomas harbors activating BRAF mutations (over 90 % V600E). BRAFV600E has been implicated in different mechanisms underlying melanomagenesis, most of which...

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Bibliographic Details
Main Authors: Ascierto Paolo A, Kirkwood John M, Grob Jean-Jacques, Simeone Ester, Grimaldi Antonio M, Maio Michele, Palmieri Giuseppe, Testori Alessandro, Marincola Francesco M, Mozzillo Nicola
Format: Article
Language:English
Published: BMC 2012-07-01
Series:Journal of Translational Medicine
Subjects:
BRAF
Vemurafenib
Melanoma
Online Access:http://www.translational-medicine.com/content/10/1/85

Internet

http://www.translational-medicine.com/content/10/1/85

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