Treponema denticola dentilisin triggered TLR2/MyD88 activation upregulates a tissue destructive program involving MMPs via Sp1 in human oral cells.

Treponema denticola dentilisin triggered TLR2/MyD88 activation upregulates a tissue destructive program involving MMPs via Sp1 in human oral cells.

Periodontal disease is driven by dysbiosis in the oral microbiome, resulting in over-representation of species that induce the release of pro-inflammatory cytokines, chemokines, and tissue-remodeling matrix metalloproteinases (MMPs) in the periodontium. These chronic tissue-destructive inflammatory...

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Bibliographic Details
Main Authors: Sean Ganther, Allan Radaic, Erin Malone, Pachiyappan Kamarajan, Nai-Yuan Nicholas Chang, Christian Tafolla, Ling Zhan, J Christopher Fenno, Yvonne L Kapila
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009311

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https://doi.org/10.1371/journal.ppat.1009311

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