Fatty acid oxidation of alternatively activated macrophages prevents foam cell formation, but Mycobacterium tuberculosis counteracts this process via HIF-1α activation.

Fatty acid oxidation of alternatively activated macrophages prevents foam cell formation, but Mycobacterium tuberculosis counteracts this process via HIF-1α activation.

The ability of Mycobacterium tuberculosis (Mtb) to persist inside host cells relies on metabolic adaptation, like the accumulation of lipid bodies (LBs) in the so-called foamy macrophages (FM), which are favorable to Mtb. The activation state of macrophages is tightly associated to different metabol...

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Bibliographic Details
Main Authors: Melanie Genoula, José Luis Marín Franco, Mariano Maio, Belén Dolotowicz, Malena Ferreyra, M Ayelén Milillo, Rémi Mascarau, Eduardo José Moraña, Domingo Palmero, Mario Matteo, Federico Fuentes, Beatriz López, Paula Barrionuevo, Olivier Neyrolles, Céline Cougoule, Geanncarlo Lugo-Villarino, Christel Vérollet, María Del Carmen Sasiain, Luciana Balboa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-10-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008929

Internet

https://doi.org/10.1371/journal.ppat.1008929

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