Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms

Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms

The Arp2/3 complex regulates many cellular processes by stimulating formation of branched actin filament networks. Because three of its seven subunits exist as two different isoforms, mammals produce a family of Arp2/3 complexes with different properties that may be suited to different physiological...

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Bibliographic Details
Main Authors: Ottilie von Loeffelholz, Andrew Purkiss, Luyan Cao, Svend Kjaer, Naoko Kogata, Guillaume Romet-Lemonne, Michael Way, Carolyn A. Moores
Format: Article
Language:English
Published: The Company of Biologists 2020-07-01
Series:Biology Open
Subjects:
arp2/3
actin
cytoskeleton
cryo-em
isoforms
nucleation
Online Access:http://bio.biologists.org/content/9/7/bio054304

Internet

http://bio.biologists.org/content/9/7/bio054304

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