Coating of Mesh Grafts for Prolapse and Urinary Incontinence Repair with Autologous Plasma: Exploration Stage of a Surgical Innovation
Purpose. Optimized biocompatibility is a major requirement for alloplastic materials currently applied for stress urinary incontinence (SUI) and pelvic organ prolapse (POP) repair. In the preliminary studies the mesh modification by coating with autologous plasma resulted in the increased adherence...
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Online Access: | http://dx.doi.org/10.1155/2014/296498 |
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doaj-e40957352d624733a8637b455ce8fc142020-11-24T20:50:10ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/296498296498Coating of Mesh Grafts for Prolapse and Urinary Incontinence Repair with Autologous Plasma: Exploration Stage of a Surgical InnovationDimitri Barski0Holger Gerullis1Evangelos Georgas2Andreas Bär3Bernhard Lammers4Albert Ramon5Dirk Ysebaert6Bernd Klosterhalfen7Mihaly Boros8Thomas Otto9Department of Urology, Lukas Hospital, 41464 Neuss, GermanyDepartment of Urology, Lukas Hospital, 41464 Neuss, GermanyDepartment of Urology, Lukas Hospital, 41464 Neuss, GermanyDepartment of Surgery, Lukas Hospital, 41464 Neuss, GermanyDepartment of Surgery, Lukas Hospital, 41464 Neuss, GermanyITERA (International Tissue Engineering Research Association), 2000 Antwerpen, BelgiumDepartment of Surgery, University of Antwerpen, 2000 Antwerpen, BelgiumGerman Centre for Implant-Pathology, 52351 Düren, GermanyDepartment of Experimental Surgery, University of Szeged, H-6720 Szeged, HungaryDepartment of Urology, Lukas Hospital, 41464 Neuss, GermanyPurpose. Optimized biocompatibility is a major requirement for alloplastic materials currently applied for stress urinary incontinence (SUI) and pelvic organ prolapse (POP) repair. In the preliminary studies the mesh modification by coating with autologous plasma resulted in the increased adherence score in vitro and improved biocompatibility in an animal model. The first use of plasma coated meshes in human is presented. Materials and Methods. Between 04/2013 and 05/2014, 20 patients with the indication for SUI and POP repair were selected in a single institution. The applied meshes were modified by autologous plasma coating prior to implantation. A retrospective chart review for peri- and early postoperative complications was performed. Functional outcome and QoL were evaluated pre- and postoperatively. Results. The functional outcome and QoL improved significantly in all groups. Two reoperations (Grade IIIB) with the release of TVT-mesh in anesthesia due to the obstruction were needed. No other severe complications were registered. Conclusion. For the first time we applied a mesh modification in a human setting according to IDEAL criteria of surgical innovations. The procedure of mesh coating with autologous plasma is safe and a prospective randomized trial proving a positive effect of plasma coating on the biocompatibility and morbidity outcome with long-term registry is planned.http://dx.doi.org/10.1155/2014/296498 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dimitri Barski Holger Gerullis Evangelos Georgas Andreas Bär Bernhard Lammers Albert Ramon Dirk Ysebaert Bernd Klosterhalfen Mihaly Boros Thomas Otto |
spellingShingle |
Dimitri Barski Holger Gerullis Evangelos Georgas Andreas Bär Bernhard Lammers Albert Ramon Dirk Ysebaert Bernd Klosterhalfen Mihaly Boros Thomas Otto Coating of Mesh Grafts for Prolapse and Urinary Incontinence Repair with Autologous Plasma: Exploration Stage of a Surgical Innovation BioMed Research International |
author_facet |
Dimitri Barski Holger Gerullis Evangelos Georgas Andreas Bär Bernhard Lammers Albert Ramon Dirk Ysebaert Bernd Klosterhalfen Mihaly Boros Thomas Otto |
author_sort |
Dimitri Barski |
title |
Coating of Mesh Grafts for Prolapse and Urinary Incontinence Repair with Autologous Plasma: Exploration Stage of a Surgical Innovation |
title_short |
Coating of Mesh Grafts for Prolapse and Urinary Incontinence Repair with Autologous Plasma: Exploration Stage of a Surgical Innovation |
title_full |
Coating of Mesh Grafts for Prolapse and Urinary Incontinence Repair with Autologous Plasma: Exploration Stage of a Surgical Innovation |
title_fullStr |
Coating of Mesh Grafts for Prolapse and Urinary Incontinence Repair with Autologous Plasma: Exploration Stage of a Surgical Innovation |
title_full_unstemmed |
Coating of Mesh Grafts for Prolapse and Urinary Incontinence Repair with Autologous Plasma: Exploration Stage of a Surgical Innovation |
title_sort |
coating of mesh grafts for prolapse and urinary incontinence repair with autologous plasma: exploration stage of a surgical innovation |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2014-01-01 |
description |
Purpose. Optimized biocompatibility is a major requirement for alloplastic materials currently applied for stress urinary incontinence (SUI) and pelvic organ prolapse (POP) repair. In the preliminary studies the mesh modification by coating with autologous plasma resulted in the increased adherence score in vitro and improved biocompatibility in an animal model. The first use of plasma coated meshes in human is presented. Materials and Methods. Between 04/2013 and 05/2014, 20 patients with the indication for SUI and POP repair were selected in a single institution. The applied meshes were modified by autologous plasma coating prior to implantation. A retrospective chart review for peri- and early postoperative complications was performed. Functional outcome and QoL were evaluated pre- and postoperatively. Results. The functional outcome and QoL improved significantly in all groups. Two reoperations (Grade IIIB) with the release of TVT-mesh in anesthesia due to the obstruction were needed. No other severe complications were registered. Conclusion. For the first time we applied a mesh modification in a human setting according to IDEAL criteria of surgical innovations. The procedure of mesh coating with autologous plasma is safe and a prospective randomized trial proving a positive effect of plasma coating on the biocompatibility and morbidity outcome with long-term registry is planned. |
url |
http://dx.doi.org/10.1155/2014/296498 |
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