c-Jun N-Terminal Kinase Phosphorylation Is a Biomarker of Plitidepsin Activity

c-Jun N-Terminal Kinase Phosphorylation Is a Biomarker of Plitidepsin Activity

Plitidepsin is an antitumor drug of marine origin currently in Phase III clinical trials in multiple myeloma. In cultured cells, plitidepsin induces cell cycle arrest or an acute apoptotic process in which sustained activation of c-Jun N-terminal kinase (JNK) plays a crucial role. With a view to opt...

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Bibliographic Details
Main Authors: Alberto Muñoz, Pablo Avilés, Carlos M. Galmarini, Marina Pollán, María J. Muñoz-Alonso, Enrique Álvarez, María José Guillén-Navarro
Format: Article
Language:English
Published: MDPI AG 2013-05-01
Series:Marine Drugs
Subjects:
plitidepsin
Aplidin
JNK
biomarker
xenograft
Online Access:http://www.mdpi.com/1660-3397/11/5/1677

Internet

http://www.mdpi.com/1660-3397/11/5/1677

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