Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer’s disease model

Arrayed CRISPR reveals genetic regulators of tau aggregation, autophagy and mitochondria in Alzheimer’s disease model

Abstract Alzheimer’s disease (AD) is a common neurodegenerative disease with poor prognosis. New options for drug discovery targets are needed. We developed an imaging based arrayed CRISPR method to interrogate the human genome for modulation of in vitro correlates of AD features, and used this to a...

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Bibliographic Details
Main Authors: Lishu Duan, Mufeng Hu, Joseph A. Tamm, Yelena Y. Grinberg, Fang Shen, Yating Chai, Hualin Xi, Lauren Gibilisco, Brinda Ravikumar, Vivek Gautam, Eric Karran, Matthew Townsend, Robert V. Talanian
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-82658-7

Internet

https://doi.org/10.1038/s41598-021-82658-7

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