Autophagy induction promotes renal cyst growth in polycystic kidney disease

Autophagy induction promotes renal cyst growth in polycystic kidney disease

Background: Polycystic kidney disease (PKD) involves renal cysts arising from proliferating tubular cells. Autophagy has been recently suggested as a potential therapeutic target in PKD, and mammalian target of rapamycin (mTOR) is a key negative regulator of autophagy. However, the effect of autopha...

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Bibliographic Details
Main Authors: Eun Ji Lee, Je Yeong Ko, Sumin Oh, Jaehee Jun, Hyowon Mun, Chae Ji Lim, Seungwoon Seo, Hyuk Wan Ko, Hyunho Kim, Yun Kyu Oh, Curie Ahn, Minyong Kang, Min Jung Kim, Kyung Hyun Yoo, Goo Taeg Oh, Jong Hoon Park
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:EBioMedicine
Subjects:
Polycystic kidney
PKD
Autophagy
Ift46
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420303625

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http://www.sciencedirect.com/science/article/pii/S2352396420303625

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