Components of the plasminogen activation system promote engraftment of porous polyethylene biomaterial via common and distinct effects.

Rapid fibrovascularization is a prerequisite for successful biomaterial engraftment. In addition to their well-known roles in fibrinolysis, urokinase-type plasminogen activator (uPA) and tissue plasminogen activator (tPA) or their inhibitor plasminogen activator inhibitor-1 (PAI-1) have recently bee...

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Bibliographic Details
Main Authors: Christoph A Reichel, Maximilian E T Hessenauer, Kerstin Pflieger, Markus Rehberg, Sandip M Kanse, Stefan Zahler, Fritz Krombach, Alexander Berghaus, Sebastian Strieth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4319722?pdf=render