Synthesis of new annulated pyrano[2,3-d]pyrimidine derivatives using organo catalyst (DABCO) in aqueous media

A selective method for the synthesis of annulated pyrano[2,3-d]pyrimidines has been developed. It was shown that base catalysis is more efficient in this reaction, rather than acid catalysis as it is believed that 1,4-diazabicyclo[2.2.2]octane (DABCO) is N-type base catalyst used for the synthesis o...

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Main Authors: Ajmal R. Bhat, Aabid H. Shalla, Rajendra S. Dongre
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Journal of Saudi Chemical Society
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1319610314000544
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spelling doaj-e4e5bbda5b654e51b7547c849ebafcbc2020-11-25T00:05:06ZengElsevierJournal of Saudi Chemical Society1319-61032017-01-0121S1S305S31010.1016/j.jscs.2014.03.008Synthesis of new annulated pyrano[2,3-d]pyrimidine derivatives using organo catalyst (DABCO) in aqueous mediaAjmal R. Bhat0Aabid H. Shalla1Rajendra S. Dongre2Department of Chemistry, RTM Nagpur University, Nagpur 440033, IndiaIslamic University of Science and Technology, Kashmir 192122, IndiaDepartment of Chemistry, RTM Nagpur University, Nagpur 440033, IndiaA selective method for the synthesis of annulated pyrano[2,3-d]pyrimidines has been developed. It was shown that base catalysis is more efficient in this reaction, rather than acid catalysis as it is believed that 1,4-diazabicyclo[2.2.2]octane (DABCO) is N-type base catalyst used for the synthesis of pyrano[2,3-d]pyramidine derivatives via one-pot three component condensation reactions of various aromatic aldehydes, active methylene compounds and barbituric acid in aqueous ethanol carried at normal temperature. The potential application of DABCO in organic synthesis increasing rapidly because of its reaction simplicity, less pollution, and minimum reaction time, high yields of the biological active products, uses less toxic solvents and low cost chemicals.http://www.sciencedirect.com/science/article/pii/S1319610314000544Aromatic aldehydesEthylcyanoacetateBarbituric acidEthanol:waterPyrano[2,3-d]pyrimidinesDABCO catalyst
collection DOAJ
language English
format Article
sources DOAJ
author Ajmal R. Bhat
Aabid H. Shalla
Rajendra S. Dongre
spellingShingle Ajmal R. Bhat
Aabid H. Shalla
Rajendra S. Dongre
Synthesis of new annulated pyrano[2,3-d]pyrimidine derivatives using organo catalyst (DABCO) in aqueous media
Journal of Saudi Chemical Society
Aromatic aldehydes
Ethylcyanoacetate
Barbituric acid
Ethanol:water
Pyrano[2,3-d]pyrimidines
DABCO catalyst
author_facet Ajmal R. Bhat
Aabid H. Shalla
Rajendra S. Dongre
author_sort Ajmal R. Bhat
title Synthesis of new annulated pyrano[2,3-d]pyrimidine derivatives using organo catalyst (DABCO) in aqueous media
title_short Synthesis of new annulated pyrano[2,3-d]pyrimidine derivatives using organo catalyst (DABCO) in aqueous media
title_full Synthesis of new annulated pyrano[2,3-d]pyrimidine derivatives using organo catalyst (DABCO) in aqueous media
title_fullStr Synthesis of new annulated pyrano[2,3-d]pyrimidine derivatives using organo catalyst (DABCO) in aqueous media
title_full_unstemmed Synthesis of new annulated pyrano[2,3-d]pyrimidine derivatives using organo catalyst (DABCO) in aqueous media
title_sort synthesis of new annulated pyrano[2,3-d]pyrimidine derivatives using organo catalyst (dabco) in aqueous media
publisher Elsevier
series Journal of Saudi Chemical Society
issn 1319-6103
publishDate 2017-01-01
description A selective method for the synthesis of annulated pyrano[2,3-d]pyrimidines has been developed. It was shown that base catalysis is more efficient in this reaction, rather than acid catalysis as it is believed that 1,4-diazabicyclo[2.2.2]octane (DABCO) is N-type base catalyst used for the synthesis of pyrano[2,3-d]pyramidine derivatives via one-pot three component condensation reactions of various aromatic aldehydes, active methylene compounds and barbituric acid in aqueous ethanol carried at normal temperature. The potential application of DABCO in organic synthesis increasing rapidly because of its reaction simplicity, less pollution, and minimum reaction time, high yields of the biological active products, uses less toxic solvents and low cost chemicals.
topic Aromatic aldehydes
Ethylcyanoacetate
Barbituric acid
Ethanol:water
Pyrano[2,3-d]pyrimidines
DABCO catalyst
url http://www.sciencedirect.com/science/article/pii/S1319610314000544
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