Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells

Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells

It is recognized that cellular senescence is triggered by DNA damage as a protective mechanism against tumorigenesis. Here the authors show that DNA single-strand breaks of oxidative origin can induce a transient senescent state followed by the emergence of clonal transformed cells.

Bibliographic Details
Main Authors: Joe Nassour, Sébastien Martien, Nathalie Martin, Emeric Deruy, Elisa Tomellini, Nicolas Malaquin, Fatima Bouali, Laure Sabatier, Nicolas Wernert, Sébastien Pinte, Eric Gilson, Albin Pourtier, Olivier Pluquet, Corinne Abbadie
Format: Article
Language:English
Published: Nature Publishing Group 2016-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10399

Internet

https://doi.org/10.1038/ncomms10399

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