A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.

A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.

Serum bilirubin levels have been associated with polymorphisms in the UGT1A1 promoter in normal populations and in patients with hemolytic anemias, including sickle cell anemia. When hemolysis occurs circulating heme increases, leading to elevated bilirubin levels and an increased incidence of chole...

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Bibliographic Details
Main Authors: Jacqueline N Milton, Paola Sebastiani, Nadia Solovieff, Stephen W Hartley, Pallav Bhatnagar, Dan E Arking, Daniel A Dworkis, James F Casella, Emily Barron-Casella, Christopher J Bean, W Craig Hooper, Michael R DeBaun, Melanie E Garrett, Karen Soldano, Marilyn J Telen, Allison Ashley-Koch, Mark T Gladwin, Clinton T Baldwin, Martin H Steinberg, Elizabeth S Klings
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3338756?pdf=render

Internet

http://europepmc.org/articles/PMC3338756?pdf=render

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