Heparan Sulfate: A Ubiquitous Glycosaminoglycan with Multiple Roles in Immunity

Heparan sulfate (HS) is a highly acidic linear polysaccharide with a very variable structure. It is ubiquitously expressed on cell surfaces and in the extracellular matrix and basement membrane of mammalian tissues. Synthesized attached to various core proteins to form HS-proteoglycans, HS is capabl...

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Bibliographic Details
Main Authors: David Anak Simon Davis, Christopher R. Parish
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Immunology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2013.00470/full