A Physiology-Based Model of Human Bile Acid Metabolism for Predicting Bile Acid Tissue Levels After Drug Administration in Healthy Subjects and BRIC Type 2 Patients

A Physiology-Based Model of Human Bile Acid Metabolism for Predicting Bile Acid Tissue Levels After Drug Administration in Healthy Subjects and BRIC Type 2 Patients

Drug-induced liver injury (DILI) is a matter of concern in the course of drug development and patient safety, often leading to discontinuation of drug-development programs or early withdrawal of drugs from market. Hepatocellular toxicity or impairment of bile acid (BA) metabolism, known as cholestas...

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Bibliographic Details
Main Authors: Vanessa Baier, Henrik Cordes, Christoph Thiel, José V. Castell, Ulf P. Neumann, Lars M. Blank, Lars Kuepfer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Physiology
Subjects:
PBPK
computational modelling
DILI
bile acids
BRIC type 2
cholestasis
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01192/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.01192/full

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