Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia

Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia

MLL-rearranged leukemia depends on H3K79 methylation. Depletion of this transcriptionally activating mark by DOT1L deletion or high concentrations of the inhibitor pinometostat downregulates HOXA9 and MEIS1, and consequently reduces leukemia survival. Yet, some MLL-rearranged leukemias are inexplica...

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Bibliographic Details
Main Authors: William F Richter, Rohan N Shah, Alexander J Ruthenburg
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
chromatin
leukemia
MLL-rearranged
H3K79me2
MV4;11
FLT3
Online Access:https://elifesciences.org/articles/64960

Internet

https://elifesciences.org/articles/64960

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