Use of weighted multivariate estimates in trials of multi-serotype vaccines to simplify interpretation of treatment differences.

Use of weighted multivariate estimates in trials of multi-serotype vaccines to simplify interpretation of treatment differences.

Many vaccines contain multiple components. Licensed pneumococcal conjugate vaccines (PCV) contain polysaccharides from 7, 10, or 13 different serotypes of Streptococcus pneumoniae. The main outcomes in randomised trials of pneumococcal vaccines are serotype-specific antibody measures. Comparisons ar...

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Bibliographic Details
Main Authors: Merryn Voysey, Andrew J Pollard, Rafael Perera, Shrijana Shrestha, Stephen Thorson, Thomas R Fanshawe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5922548?pdf=render

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http://europepmc.org/articles/PMC5922548?pdf=render

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