Small molecules with similar structures exhibit agonist, neutral antagonist or inverse agonist activity toward angiotensin II type 1 receptor.
Small differences in the chemical structures of ligands can be responsible for agonism, neutral antagonism or inverse agonism toward a G-protein-coupled receptor (GPCR). Although each ligand may stabilize the receptor conformation in a different way, little is known about the precise conformational...
Main Authors: | Shin-ichiro Miura, Yoshihiro Kiya, Hiroyuki Hanzawa, Naoki Nakao, Masahiro Fujino, Satoshi Imaizumi, Yoshino Matsuo, Hiroaki Yanagisawa, Hiroyuki Koike, Issei Komuro, Sadashiva S Karnik, Keijiro Saku |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3375280?pdf=render |
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