Colonization of distant organs by tumor cells generating circulating homotypic clusters adaptive to fluid shear stress

Colonization of distant organs by tumor cells generating circulating homotypic clusters adaptive to fluid shear stress

Abstract Once disseminated tumor cells (DTCs) arrive at a metastatic organ, they remain there, latent, and become seeds of metastasis. However, the clonal composition of DTCs in a latent state remains unclear. Here, we applied high-resolution DNA barcode tracking to a mouse model that recapitulated...

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Bibliographic Details
Main Authors: Manabu Maeshiro, Satoru Shinriki, Rin Liu, Yutaka Nakachi, Yoshihiro Komohara, Yukio Fujiwara, Kazuaki Ohtsubo, Ryoji Yoshida, Kazuya Iwamoto, Hideki Nakayama, Hirotaka Matsui
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-85743-z

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https://doi.org/10.1038/s41598-021-85743-z

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