Toward Developing a Preventive MERS-CoV Vaccine—Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14–15, 2015
Middle East respiratory syndrome (MERS) remains a serious international public health threat. With the goal of accelerating the development of countermeasures against MERS coronavirus (MERS-CoV), funding agencies, nongovernmental organizations, and researchers across the world assembled in Riyadh, S...
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doaj-e76968a6cac344dcb5861951433ca2c42020-11-24T21:45:59ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592016-08-0122810.3201/eid2208.160229Toward Developing a Preventive MERS-CoV Vaccine—Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14–15, 2015Jean-Louis ExclerChristopher J. DelvecchioRyan E. WileyMarni WilliamsIn-Kyu YoonKayvon ModjarradMohamed BoujelalVasee S. MoorthyAhmad Salah HersiJerome H. KimMiddle East respiratory syndrome (MERS) remains a serious international public health threat. With the goal of accelerating the development of countermeasures against MERS coronavirus (MERS-CoV), funding agencies, nongovernmental organizations, and researchers across the world assembled in Riyadh, Saudi Arabia, on November 14–15, 2015, to discuss vaccine development challenges. The meeting was spearheaded by the Saudi Ministry of Health and co-organized by the International Vaccine Institute, South Korea. Accelerating the development of a preventive vaccine requires a better understanding of MERS epidemiology, transmission, and pathogenesis in humans and animals. A combination of rodent and nonhuman primate models should be considered in evaluating and developing preventive and therapeutic vaccine candidates. Dromedary camels should be considered for the development of veterinary vaccines. Several vaccine technology platforms targeting the MERS-CoV spike protein were discussed. Mechanisms to maximize investment, provide robust data, and affect public health are urgently needed.https://wwwnc.cdc.gov/eid/article/22/8/16-0229_articleMERS-CoVcoronavirusanimal modelsvaccinepreventiontherapeutic antibodies |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jean-Louis Excler Christopher J. Delvecchio Ryan E. Wiley Marni Williams In-Kyu Yoon Kayvon Modjarrad Mohamed Boujelal Vasee S. Moorthy Ahmad Salah Hersi Jerome H. Kim |
spellingShingle |
Jean-Louis Excler Christopher J. Delvecchio Ryan E. Wiley Marni Williams In-Kyu Yoon Kayvon Modjarrad Mohamed Boujelal Vasee S. Moorthy Ahmad Salah Hersi Jerome H. Kim Toward Developing a Preventive MERS-CoV Vaccine—Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14–15, 2015 Emerging Infectious Diseases MERS-CoV coronavirus animal models vaccine prevention therapeutic antibodies |
author_facet |
Jean-Louis Excler Christopher J. Delvecchio Ryan E. Wiley Marni Williams In-Kyu Yoon Kayvon Modjarrad Mohamed Boujelal Vasee S. Moorthy Ahmad Salah Hersi Jerome H. Kim |
author_sort |
Jean-Louis Excler |
title |
Toward Developing a Preventive MERS-CoV Vaccine—Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14–15, 2015 |
title_short |
Toward Developing a Preventive MERS-CoV Vaccine—Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14–15, 2015 |
title_full |
Toward Developing a Preventive MERS-CoV Vaccine—Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14–15, 2015 |
title_fullStr |
Toward Developing a Preventive MERS-CoV Vaccine—Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14–15, 2015 |
title_full_unstemmed |
Toward Developing a Preventive MERS-CoV Vaccine—Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14–15, 2015 |
title_sort |
toward developing a preventive mers-cov vaccine—report from a workshop organized by the saudi arabia ministry of health and the international vaccine institute, riyadh, saudi arabia, november 14–15, 2015 |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2016-08-01 |
description |
Middle East respiratory syndrome (MERS) remains a serious international public health threat. With the goal of accelerating the development of countermeasures against MERS coronavirus (MERS-CoV), funding agencies, nongovernmental organizations, and researchers across the world assembled in Riyadh, Saudi Arabia, on November 14–15, 2015, to discuss vaccine development challenges. The meeting was spearheaded by the Saudi Ministry of Health and co-organized by the International Vaccine Institute, South Korea. Accelerating the development of a preventive vaccine requires a better understanding of MERS epidemiology, transmission, and pathogenesis in humans and animals. A combination of rodent and nonhuman primate models should be considered in evaluating and developing preventive and therapeutic vaccine candidates. Dromedary camels should be considered for the development of veterinary vaccines. Several vaccine technology platforms targeting the MERS-CoV spike protein were discussed. Mechanisms to maximize investment, provide robust data, and affect public health are urgently needed. |
topic |
MERS-CoV coronavirus animal models vaccine prevention therapeutic antibodies |
url |
https://wwwnc.cdc.gov/eid/article/22/8/16-0229_article |
work_keys_str_mv |
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