Renal temperature reduction progressively favors mitochondrial ROS production over respiration in hypothermic kidney preservation

Renal temperature reduction progressively favors mitochondrial ROS production over respiration in hypothermic kidney preservation

Abstract Background Hypothermia, leading to mitochondrial inhibition, is widely used to reduce ischemic injury during kidney preservation. However, the exact effect of hypothermic kidney preservation on mitochondrial function remains unclear. Methods We evaluated mitochondrial function [i.e. oxygen...

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Bibliographic Details
Main Authors: Koen D. W. Hendriks, Isabel M. A. Brüggenwirth, Hanno Maassen, Albert Gerding, Barbara Bakker, Robert J. Porte, Robert H. Henning, Henri G. D. Leuvenink
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Journal of Translational Medicine
Subjects:
Machine perfusion
Hypothermic preservation
Kidney transplantation
Reactive oxygen species
Mitochondrial function
Online Access:http://link.springer.com/article/10.1186/s12967-019-2013-1

Internet

http://link.springer.com/article/10.1186/s12967-019-2013-1

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