An Imatinib–non‐responsive patient with an ABL Leu387Trp mutation achieves cytogenetic and molecular response under bosutinib: Case report and biological characterization

Abstract Leu387Trp mutation, aroused in an imatinib‐non‐responsive CML patient, was selected by imatinib treatment along with other unknown factors responsible for resistance, and then it was overcome by bosutinib. These results will be useful for treating patients with this rare mutation and will a...

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Bibliographic Details
Main Authors: Ilaria Crespiatico, Elisa Bossi, Filippo Brioschi, Rocco Piazza, Luca Mologni, Carlo Gambacorti‐Passerini
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Clinical Case Reports
Subjects:
TKI
Online Access:https://doi.org/10.1002/ccr3.2531