Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey

Genetic medicine is one of the key components of personalized medicine, but adoption in clinical practice is still limited. To understand potential barriers and provider attitudes, we surveyed 285 physicians from five Implementing GeNomics In pracTicE (IGNITE) sites about their perceptions as to the...

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Main Authors: Aniwaa Owusu Obeng, Kezhen Fei, Kenneth D. Levy, Amanda R. Elsey, Toni I. Pollin, Andrea H. Ramirez, Kristin W. Weitzel, Carol R. Horowitz
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Journal of Personalized Medicine
Subjects:
Online Access:http://www.mdpi.com/2075-4426/8/3/24
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spelling doaj-e78f9b4aacd548ea920f0c66afa969932020-11-25T01:08:07ZengMDPI AGJournal of Personalized Medicine2075-44262018-07-01832410.3390/jpm8030024jpm8030024Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network SurveyAniwaa Owusu Obeng0Kezhen Fei1Kenneth D. Levy2Amanda R. Elsey3Toni I. Pollin4Andrea H. Ramirez5Kristin W. Weitzel6Carol R. Horowitz7The Charles Bronfman Institute for Personalized Medicine and Department of Genetics and Genomic Sciences, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USACenter for Health Equity and Community-Engaged Research, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USADivision of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, 950 W. Walnut Street, Indianapolis, IN 46202, USADepartment of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL 32640, USAProgram for Personalized and Genomic Medicine, Departments of Medicine and Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USADepartment of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USADepartment of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL 32640, USACenter for Health Equity and Community-Engaged Research, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USAGenetic medicine is one of the key components of personalized medicine, but adoption in clinical practice is still limited. To understand potential barriers and provider attitudes, we surveyed 285 physicians from five Implementing GeNomics In pracTicE (IGNITE) sites about their perceptions as to the clinical utility of genetic data as well as their preparedness to integrate it into practice. These responses were also analyzed in comparison to the type of study occurring at the physicians’ institution (pharmacogenetics versus disease genetics). The majority believed that genetic testing is clinically useful; however, only a third believed that they had obtained adequate training to care for genetically “high-risk” patients. Physicians involved in pharmacogenetics initiatives were more favorable towards genetic testing applications; they found it to be clinically useful and felt more prepared and confident in their abilities to adopt it into their practice in comparison to those participating in disease genetics initiatives. These results suggest that investigators should explore which attributes of clinical pharmacogenetics (such as the use of simplified genetics-guided recommendations) can be implemented to improve attitudes and preparedness to implement disease genetics in care. Most physicians felt unprepared to use genetic information in their practice; accordingly, major steps should be taken to develop effective clinical tools and training strategies for physicians.http://www.mdpi.com/2075-4426/8/3/24genetic medicinepharmacogeneticschronic diseasegenetic testingphysician attitudesbarriersclinical implementationclinical utilityphysician education
collection DOAJ
language English
format Article
sources DOAJ
author Aniwaa Owusu Obeng
Kezhen Fei
Kenneth D. Levy
Amanda R. Elsey
Toni I. Pollin
Andrea H. Ramirez
Kristin W. Weitzel
Carol R. Horowitz
spellingShingle Aniwaa Owusu Obeng
Kezhen Fei
Kenneth D. Levy
Amanda R. Elsey
Toni I. Pollin
Andrea H. Ramirez
Kristin W. Weitzel
Carol R. Horowitz
Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey
Journal of Personalized Medicine
genetic medicine
pharmacogenetics
chronic disease
genetic testing
physician attitudes
barriers
clinical implementation
clinical utility
physician education
author_facet Aniwaa Owusu Obeng
Kezhen Fei
Kenneth D. Levy
Amanda R. Elsey
Toni I. Pollin
Andrea H. Ramirez
Kristin W. Weitzel
Carol R. Horowitz
author_sort Aniwaa Owusu Obeng
title Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey
title_short Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey
title_full Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey
title_fullStr Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey
title_full_unstemmed Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey
title_sort physician-reported benefits and barriers to clinical implementation of genomic medicine: a multi-site ignite-network survey
publisher MDPI AG
series Journal of Personalized Medicine
issn 2075-4426
publishDate 2018-07-01
description Genetic medicine is one of the key components of personalized medicine, but adoption in clinical practice is still limited. To understand potential barriers and provider attitudes, we surveyed 285 physicians from five Implementing GeNomics In pracTicE (IGNITE) sites about their perceptions as to the clinical utility of genetic data as well as their preparedness to integrate it into practice. These responses were also analyzed in comparison to the type of study occurring at the physicians’ institution (pharmacogenetics versus disease genetics). The majority believed that genetic testing is clinically useful; however, only a third believed that they had obtained adequate training to care for genetically “high-risk” patients. Physicians involved in pharmacogenetics initiatives were more favorable towards genetic testing applications; they found it to be clinically useful and felt more prepared and confident in their abilities to adopt it into their practice in comparison to those participating in disease genetics initiatives. These results suggest that investigators should explore which attributes of clinical pharmacogenetics (such as the use of simplified genetics-guided recommendations) can be implemented to improve attitudes and preparedness to implement disease genetics in care. Most physicians felt unprepared to use genetic information in their practice; accordingly, major steps should be taken to develop effective clinical tools and training strategies for physicians.
topic genetic medicine
pharmacogenetics
chronic disease
genetic testing
physician attitudes
barriers
clinical implementation
clinical utility
physician education
url http://www.mdpi.com/2075-4426/8/3/24
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