Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey
Genetic medicine is one of the key components of personalized medicine, but adoption in clinical practice is still limited. To understand potential barriers and provider attitudes, we surveyed 285 physicians from five Implementing GeNomics In pracTicE (IGNITE) sites about their perceptions as to the...
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doaj-e78f9b4aacd548ea920f0c66afa969932020-11-25T01:08:07ZengMDPI AGJournal of Personalized Medicine2075-44262018-07-01832410.3390/jpm8030024jpm8030024Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network SurveyAniwaa Owusu Obeng0Kezhen Fei1Kenneth D. Levy2Amanda R. Elsey3Toni I. Pollin4Andrea H. Ramirez5Kristin W. Weitzel6Carol R. Horowitz7The Charles Bronfman Institute for Personalized Medicine and Department of Genetics and Genomic Sciences, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USACenter for Health Equity and Community-Engaged Research, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USADivision of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, 950 W. Walnut Street, Indianapolis, IN 46202, USADepartment of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL 32640, USAProgram for Personalized and Genomic Medicine, Departments of Medicine and Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USADepartment of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USADepartment of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL 32640, USACenter for Health Equity and Community-Engaged Research, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USAGenetic medicine is one of the key components of personalized medicine, but adoption in clinical practice is still limited. To understand potential barriers and provider attitudes, we surveyed 285 physicians from five Implementing GeNomics In pracTicE (IGNITE) sites about their perceptions as to the clinical utility of genetic data as well as their preparedness to integrate it into practice. These responses were also analyzed in comparison to the type of study occurring at the physicians’ institution (pharmacogenetics versus disease genetics). The majority believed that genetic testing is clinically useful; however, only a third believed that they had obtained adequate training to care for genetically “high-risk” patients. Physicians involved in pharmacogenetics initiatives were more favorable towards genetic testing applications; they found it to be clinically useful and felt more prepared and confident in their abilities to adopt it into their practice in comparison to those participating in disease genetics initiatives. These results suggest that investigators should explore which attributes of clinical pharmacogenetics (such as the use of simplified genetics-guided recommendations) can be implemented to improve attitudes and preparedness to implement disease genetics in care. Most physicians felt unprepared to use genetic information in their practice; accordingly, major steps should be taken to develop effective clinical tools and training strategies for physicians.http://www.mdpi.com/2075-4426/8/3/24genetic medicinepharmacogeneticschronic diseasegenetic testingphysician attitudesbarriersclinical implementationclinical utilityphysician education |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aniwaa Owusu Obeng Kezhen Fei Kenneth D. Levy Amanda R. Elsey Toni I. Pollin Andrea H. Ramirez Kristin W. Weitzel Carol R. Horowitz |
spellingShingle |
Aniwaa Owusu Obeng Kezhen Fei Kenneth D. Levy Amanda R. Elsey Toni I. Pollin Andrea H. Ramirez Kristin W. Weitzel Carol R. Horowitz Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey Journal of Personalized Medicine genetic medicine pharmacogenetics chronic disease genetic testing physician attitudes barriers clinical implementation clinical utility physician education |
author_facet |
Aniwaa Owusu Obeng Kezhen Fei Kenneth D. Levy Amanda R. Elsey Toni I. Pollin Andrea H. Ramirez Kristin W. Weitzel Carol R. Horowitz |
author_sort |
Aniwaa Owusu Obeng |
title |
Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey |
title_short |
Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey |
title_full |
Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey |
title_fullStr |
Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey |
title_full_unstemmed |
Physician-Reported Benefits and Barriers to Clinical Implementation of Genomic Medicine: A Multi-Site IGNITE-Network Survey |
title_sort |
physician-reported benefits and barriers to clinical implementation of genomic medicine: a multi-site ignite-network survey |
publisher |
MDPI AG |
series |
Journal of Personalized Medicine |
issn |
2075-4426 |
publishDate |
2018-07-01 |
description |
Genetic medicine is one of the key components of personalized medicine, but adoption in clinical practice is still limited. To understand potential barriers and provider attitudes, we surveyed 285 physicians from five Implementing GeNomics In pracTicE (IGNITE) sites about their perceptions as to the clinical utility of genetic data as well as their preparedness to integrate it into practice. These responses were also analyzed in comparison to the type of study occurring at the physicians’ institution (pharmacogenetics versus disease genetics). The majority believed that genetic testing is clinically useful; however, only a third believed that they had obtained adequate training to care for genetically “high-risk” patients. Physicians involved in pharmacogenetics initiatives were more favorable towards genetic testing applications; they found it to be clinically useful and felt more prepared and confident in their abilities to adopt it into their practice in comparison to those participating in disease genetics initiatives. These results suggest that investigators should explore which attributes of clinical pharmacogenetics (such as the use of simplified genetics-guided recommendations) can be implemented to improve attitudes and preparedness to implement disease genetics in care. Most physicians felt unprepared to use genetic information in their practice; accordingly, major steps should be taken to develop effective clinical tools and training strategies for physicians. |
topic |
genetic medicine pharmacogenetics chronic disease genetic testing physician attitudes barriers clinical implementation clinical utility physician education |
url |
http://www.mdpi.com/2075-4426/8/3/24 |
work_keys_str_mv |
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