Gender and Weight Influence Quality of Life in Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by abdominal pain and bowel dysfunction in the absence of structural abnormality. Diagnosis can be challenging and often leads to extensive medical tests, non-effective therapeutic modalities, and reduced quality of l...
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doaj-e7b4a5742b134e40a7c298d129e4cd0c2020-11-25T00:08:37ZengMDPI AGJournal of Clinical Medicine2077-03832017-11-0161110310.3390/jcm6110103jcm6110103Gender and Weight Influence Quality of Life in Irritable Bowel SyndromeLeeAnne B. Sherwin0Onyinyechi M. Ozoji1Christina M. Boulineaux2Paule V. Joseph3Nicolaas H. Fourie4Sarah K. Abey5Xuemin Zhang6Wendy A. Henderson7Sinclair School of Nursing, University of Missouri-Columbia, Columbia, MO 65211, USADigestive Disorders Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USADigestive Disorders Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USADigestive Disorders Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USADigestive Disorders Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USASchool of Nursing & Health Studies, Georgetown University, Washington, DC 20007, USADigestive Disorders Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USADigestive Disorders Unit, Biobehavioral Branch, Division of Intramural Research, National Institute of Nursing Research, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USAIrritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by abdominal pain and bowel dysfunction in the absence of structural abnormality. Diagnosis can be challenging and often leads to extensive medical tests, non-effective therapeutic modalities, and reduced quality of life (QOL). Identifying factors associated with dysfunction have the potential to enhance outcomes. Participants with IBS (n = 41) and healthy volunteers (n = 74) were recruited into this cross-sectional, descriptive, natural history protocol at the National Institute of Health, Clinical Center. Demographic characteristics were self-reported. QOL was assessed with the Irritable Bowel Syndrome Quality of Life (IBS-QOL) questionnaire. Statistical analysis included descriptive statistics, factorial ANOVA, and multiple regression. Individuals with IBS reported lower QOL scores across all QOL-subscales compared to healthy controls. Normal-weight women and overweight men with IBS reported the greatest QOL impairment. Body fat percent had confounding effects on the relationship between IBS and QOL. The disparity between QOL scores in participants with IBS by both gender and weight groups may reflect different social pressures perceived by normal and overweight women and men. These findings enhance the recognition of the disparities in patients with chronic symptoms and thereby lead to personalized assessment and interventions to improve their QOL.https://www.mdpi.com/2077-0383/6/11/103irritable bowel syndromequality of lifeweightgendersymptoms |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
LeeAnne B. Sherwin Onyinyechi M. Ozoji Christina M. Boulineaux Paule V. Joseph Nicolaas H. Fourie Sarah K. Abey Xuemin Zhang Wendy A. Henderson |
spellingShingle |
LeeAnne B. Sherwin Onyinyechi M. Ozoji Christina M. Boulineaux Paule V. Joseph Nicolaas H. Fourie Sarah K. Abey Xuemin Zhang Wendy A. Henderson Gender and Weight Influence Quality of Life in Irritable Bowel Syndrome Journal of Clinical Medicine irritable bowel syndrome quality of life weight gender symptoms |
author_facet |
LeeAnne B. Sherwin Onyinyechi M. Ozoji Christina M. Boulineaux Paule V. Joseph Nicolaas H. Fourie Sarah K. Abey Xuemin Zhang Wendy A. Henderson |
author_sort |
LeeAnne B. Sherwin |
title |
Gender and Weight Influence Quality of Life in Irritable Bowel Syndrome |
title_short |
Gender and Weight Influence Quality of Life in Irritable Bowel Syndrome |
title_full |
Gender and Weight Influence Quality of Life in Irritable Bowel Syndrome |
title_fullStr |
Gender and Weight Influence Quality of Life in Irritable Bowel Syndrome |
title_full_unstemmed |
Gender and Weight Influence Quality of Life in Irritable Bowel Syndrome |
title_sort |
gender and weight influence quality of life in irritable bowel syndrome |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2017-11-01 |
description |
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by abdominal pain and bowel dysfunction in the absence of structural abnormality. Diagnosis can be challenging and often leads to extensive medical tests, non-effective therapeutic modalities, and reduced quality of life (QOL). Identifying factors associated with dysfunction have the potential to enhance outcomes. Participants with IBS (n = 41) and healthy volunteers (n = 74) were recruited into this cross-sectional, descriptive, natural history protocol at the National Institute of Health, Clinical Center. Demographic characteristics were self-reported. QOL was assessed with the Irritable Bowel Syndrome Quality of Life (IBS-QOL) questionnaire. Statistical analysis included descriptive statistics, factorial ANOVA, and multiple regression. Individuals with IBS reported lower QOL scores across all QOL-subscales compared to healthy controls. Normal-weight women and overweight men with IBS reported the greatest QOL impairment. Body fat percent had confounding effects on the relationship between IBS and QOL. The disparity between QOL scores in participants with IBS by both gender and weight groups may reflect different social pressures perceived by normal and overweight women and men. These findings enhance the recognition of the disparities in patients with chronic symptoms and thereby lead to personalized assessment and interventions to improve their QOL. |
topic |
irritable bowel syndrome quality of life weight gender symptoms |
url |
https://www.mdpi.com/2077-0383/6/11/103 |
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