New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets

New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets

Several anti-inflammatory agents based on pyrazole and imidazopyrazole scaffolds and a large library of substituted catechol PDE4D inhibitors were reported by us in the recent past. To obtain new molecules potentially able to act on different targets involved in inflammation onset we designed and sy...

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Bibliographic Details
Main Authors: Chiara Brullo, Matteo Massa, Federica Rapetti, Silvana Alfei, Maria B. Bertolotto, Fabrizio Montecucco, Maria Grazia Signorello, Olga Bruno
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Molecules
Subjects:
pyrazole-4-carbohydrazides
imidazopyrazole-7-carbohydrazides
reactive oxygen production inhibition
platelets
neutrophils
phosphodiesterase inhibitors
Online Access:https://www.mdpi.com/1420-3049/25/4/899

Internet

https://www.mdpi.com/1420-3049/25/4/899

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