Whole Exome Sequencing of Cell-Free DNA for Early Lung Cancer: A Pilot Study to Differentiate Benign From Malignant CT-Detected Pulmonary Lesions

Whole Exome Sequencing of Cell-Free DNA for Early Lung Cancer: A Pilot Study to Differentiate Benign From Malignant CT-Detected Pulmonary Lesions

Introduction: Indeterminate pulmonary lesions (IPL) detected by CT pose a significant clinical challenge, frequently necessitating long-term surveillance or biopsy for diagnosis. In this pilot investigation, we performed whole exome sequencing (WES) of plasma cell free (cfDNA) and matched germline D...

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Bibliographic Details
Main Authors: Tina D. Tailor, Xiayu Rao, Michael J. Campa, Jing Wang, Simon G. Gregory, Edward F. Patz Jr.
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Oncology
Subjects:
cell free DNA
cancer detection
lung cancer—diagnosis
whole exome sequencing
pulmonary nodule
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00317/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00317/full

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