Retargeting azithromycin analogues to have dual-modality antimalarial activity

Retargeting azithromycin analogues to have dual-modality antimalarial activity

Abstract Background Resistance to front-line antimalarials (artemisinin combination therapies) is spreading, and development of new drug treatment strategies to rapidly kill Plasmodium spp. malaria parasites is urgently needed. Azithromycin is a clinically used macrolide antibiotic proposed as a par...

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Bibliographic Details
Main Authors: Amy L. Burns, Brad E. Sleebs, Ghizal Siddiqui, Amanda E. De Paoli, Dovile Anderson, Benjamin Liffner, Richard Harvey, James G. Beeson, Darren J. Creek, Christopher D. Goodman, Geoffrey I. McFadden, Danny W. Wilson
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Biology
Subjects:
Plasmodium
Malaria
Antimalarial
Macrolide
Online Access:http://link.springer.com/article/10.1186/s12915-020-00859-4

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http://link.springer.com/article/10.1186/s12915-020-00859-4

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