DiNeR: a Differential graphical model for analysis of co-regulation Network Rewiring

DiNeR: a Differential graphical model for analysis of co-regulation Network Rewiring

Abstract Background During transcription, numerous transcription factors (TFs) bind to targets in a highly coordinated manner to control the gene expression. Alterations in groups of TF-binding profiles (i.e. “co-binding changes”) can affect the co-regulating associations between TFs (i.e. “rewiring...

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Bibliographic Details
Main Authors: Jing Zhang, Jason Liu, Donghoon Lee, Shaoke Lou, Zhanlin Chen, Gamze Gürsoy, Mark Gerstein
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Bioinformatics
Subjects:
Transcription factor co-regulation network
ENCODE
TF dysregulation
Network changes
Online Access:http://link.springer.com/article/10.1186/s12859-020-03605-3

Internet

http://link.springer.com/article/10.1186/s12859-020-03605-3

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