Three dimensional printed nanostructure biomaterials for bone tissue engineering

The suffering from organ dysfunction due to damaged or diseased tissue/bone has been globally on the rise. Current treatment strategies for non-union bone defects include: the use of autografts, allografts, synthetic grafts and free vascularized fibular grafts. Bone tissue engineering has emerged as...

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Main Authors: Tesfa Marew, Gebremariam Birhanu
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Regenerative Therapy
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320421000328
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spelling doaj-e97374c5b04a401a9c4e0a58392619b42021-05-30T04:43:51ZengElsevierRegenerative Therapy2352-32042021-12-0118102111Three dimensional printed nanostructure biomaterials for bone tissue engineeringTesfa Marew0Gebremariam Birhanu1Department of Pharmaceutics & Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaCorresponding author.; Department of Pharmaceutics & Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, EthiopiaThe suffering from organ dysfunction due to damaged or diseased tissue/bone has been globally on the rise. Current treatment strategies for non-union bone defects include: the use of autografts, allografts, synthetic grafts and free vascularized fibular grafts. Bone tissue engineering has emerged as an alternative for fracture repair to satisfy the current unmet need of bone grafts and to alleviate the problems associated with autografts and allografts. The technology offers the possibility to induce new functional bone regeneration using synergistic combination of functional biomaterials (scaffolds), cells, and growth factors. Bone scaffolds are typically made of porous biodegradable materials that provide the mechanical support during repair and regeneration of damaged or diseased bone. Significant progress has been made towards scaffold materials for structural support, desired osteogenesis and angiogenesis abilities. Thanks for innovative scaffolds fabrication technologies, bioresorbable scaffolds with controlled porosity and tailored properties are possible today. Despite the presence of different bone scaffold fabrication methods, pore size, shape and interconnectivity have not yet been fully controlled in most of the methods. Moreover, scaffolds with tailored porosity for specific defects are still difficult to manufacture. Nevertheless, such scaffolds can be designed and fabricated using three dimensional (3D) printing approaches. 3D printing technology, as an advanced tissue scaffold fabrication method, offers the opportunity to produce complex geometries with distinct advantages. The technology has been used for the production of various types of bodily constructs such as blood vessels, vascular networks, bones, cartilages, exoskeletons, eyeglasses, cell cultures, tissues, organs and novel drug delivery devices. This review focuses on 3D printed scaffolds and their application in bone repair and regeneration. In addition, different classes of biomaterials commonly employed for the fabrication of 3D nano scaffolds for bone tissue engineering application so far are briefly discussed.http://www.sciencedirect.com/science/article/pii/S2352320421000328BiomaterialsBone tissue engineeringNanofiber scaffoldsThree dimensional printingNanohydroxyapitite
collection DOAJ
language English
format Article
sources DOAJ
author Tesfa Marew
Gebremariam Birhanu
spellingShingle Tesfa Marew
Gebremariam Birhanu
Three dimensional printed nanostructure biomaterials for bone tissue engineering
Regenerative Therapy
Biomaterials
Bone tissue engineering
Nanofiber scaffolds
Three dimensional printing
Nanohydroxyapitite
author_facet Tesfa Marew
Gebremariam Birhanu
author_sort Tesfa Marew
title Three dimensional printed nanostructure biomaterials for bone tissue engineering
title_short Three dimensional printed nanostructure biomaterials for bone tissue engineering
title_full Three dimensional printed nanostructure biomaterials for bone tissue engineering
title_fullStr Three dimensional printed nanostructure biomaterials for bone tissue engineering
title_full_unstemmed Three dimensional printed nanostructure biomaterials for bone tissue engineering
title_sort three dimensional printed nanostructure biomaterials for bone tissue engineering
publisher Elsevier
series Regenerative Therapy
issn 2352-3204
publishDate 2021-12-01
description The suffering from organ dysfunction due to damaged or diseased tissue/bone has been globally on the rise. Current treatment strategies for non-union bone defects include: the use of autografts, allografts, synthetic grafts and free vascularized fibular grafts. Bone tissue engineering has emerged as an alternative for fracture repair to satisfy the current unmet need of bone grafts and to alleviate the problems associated with autografts and allografts. The technology offers the possibility to induce new functional bone regeneration using synergistic combination of functional biomaterials (scaffolds), cells, and growth factors. Bone scaffolds are typically made of porous biodegradable materials that provide the mechanical support during repair and regeneration of damaged or diseased bone. Significant progress has been made towards scaffold materials for structural support, desired osteogenesis and angiogenesis abilities. Thanks for innovative scaffolds fabrication technologies, bioresorbable scaffolds with controlled porosity and tailored properties are possible today. Despite the presence of different bone scaffold fabrication methods, pore size, shape and interconnectivity have not yet been fully controlled in most of the methods. Moreover, scaffolds with tailored porosity for specific defects are still difficult to manufacture. Nevertheless, such scaffolds can be designed and fabricated using three dimensional (3D) printing approaches. 3D printing technology, as an advanced tissue scaffold fabrication method, offers the opportunity to produce complex geometries with distinct advantages. The technology has been used for the production of various types of bodily constructs such as blood vessels, vascular networks, bones, cartilages, exoskeletons, eyeglasses, cell cultures, tissues, organs and novel drug delivery devices. This review focuses on 3D printed scaffolds and their application in bone repair and regeneration. In addition, different classes of biomaterials commonly employed for the fabrication of 3D nano scaffolds for bone tissue engineering application so far are briefly discussed.
topic Biomaterials
Bone tissue engineering
Nanofiber scaffolds
Three dimensional printing
Nanohydroxyapitite
url http://www.sciencedirect.com/science/article/pii/S2352320421000328
work_keys_str_mv AT tesfamarew threedimensionalprintednanostructurebiomaterialsforbonetissueengineering
AT gebremariambirhanu threedimensionalprintednanostructurebiomaterialsforbonetissueengineering
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