Binding of Staphylococcal Enterotoxin B (SEB) to B7 Receptors Triggers TCR- and CD28-Mediated Inflammatory Signals in the Absence of MHC Class II Molecules

Binding of Staphylococcal Enterotoxin B (SEB) to B7 Receptors Triggers TCR- and CD28-Mediated Inflammatory Signals in the Absence of MHC Class II Molecules

The inflammatory activity of staphylococcal enterotoxin B (SEB) relies on its capacity to trigger polyclonal T-cell activation by binding both T-cell receptor (TCR) and costimulatory receptor CD28 on T cells and MHC class II and B7 molecules on antigen presenting cells (APC). Previous studies highli...

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Bibliographic Details
Main Authors: Martina Kunkl, Carola Amormino, Silvana Caristi, Valentina Tedeschi, Maria Teresa Fiorillo, Revital Levy, Andrey Popugailo, Raymond Kaempfer, Loretta Tuosto
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
staphylococcal enterotoxins
inflammatory response
T cells
CD28
TCR - T cell receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.723689/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.723689/full

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