Fractionation-Dependent Radiosensitization by Molecular Targeting of Nek1

Fractionation-Dependent Radiosensitization by Molecular Targeting of Nek1

NIMA (never-in-mitosis gene A)-related kinase 1 (Nek1) is shown to impact on different cellular pathways such as DNA repair, checkpoint activation, and apoptosis. Its role as a molecular target for radiation sensitization of malignant cells, however, remains elusive. Stably transduced doxycycline (D...

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Bibliographic Details
Main Authors: Isabel Freund, Stephanie Hehlgans, Daniel Martin, Michael Ensminger, Emmanouil Fokas, Claus Rödel, Markus Löbrich, Franz Rödel
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
Nek1
cervical cancer
colorectal cancer
fractionation
radiosensitization
xenograft
Online Access:https://www.mdpi.com/2073-4409/9/5/1235

Internet

https://www.mdpi.com/2073-4409/9/5/1235

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